What do PDZ domains bind?

What do PDZ domains bind?

The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. In general PDZ domains bind to a short region of the C-terminus of other specific proteins. These short regions bind to the PDZ domain by beta sheet augmentation.

Where is PSD 95 found?

PSD-95 is highly expressed in the cerebral cortex, hippocampus, and striatum, and only moderately or weakly expressed in other brain regions.

What is the meaning of PDZ?

PDZ

What is Synapsin used for?

The major functions of synapsins. These neuron-specific phosphoproteins are active in various regulatory functions at the synapses which include the formation of presynaptic terminals, regulation of the vesicle reserve pool at presynaptic terminals, synaptogenesis, elongation of axons, and synaptic vesicle docking.

What does PSD-95 do?

PSD-95 is a scaffolding protein that regulates the synaptic localization of many receptors, channels, and signaling proteins. The NLGN gene family encodes single-pass transmembrane postsynaptic cell adhesion molecules that are important for synapse assembly and function.

What is a binding curve?

An oxygen-binding curve is a plot that shows fractional saturation versus the concentration of oxygen. By definition, fractional saturation indicates the presence of binding sites that have oxygen. Fractional saturation can range from zero (all sites are empty) to one (all sites are filled).

What is Synapsin protein?

The synapsins are a family of proteins that have long been implicated in the regulation of neurotransmitter release at synapses. Specifically, they are thought to be involved in regulating the number of synaptic vesicles available for release via exocytosis at any one time.

What is SYN1 gene?

SYN1 (Synapsin I) is a Protein Coding gene. Diseases associated with SYN1 include Epilepsy, X-Linked, With Variable Learning Disabilities And Behavior Disorders and Intellectual Developmental Disorder, X-Linked 50.

What is a PDZ domain?

DOI: 10.1038/nrn1517 Abstract PDZ domains are protein-interaction domains that are often found in multi-domain scaffolding proteins. PDZ-containing scaffolds assemble specific proteins into large molecular complexes at defined locations in the cell.

Is PDZ a protein-interaction module?

PDZ domains were characterized as protein-interaction modules only a decade ago, but they have now come of age. Nowhere is the diversity and function of PDZ proteins better illustrated than at excitatory glutamatergic synapses.

Are tandem PDZ repeats in glutamate receptor interacting proteins target-mediated?

Feng, W., Shi, Y., Li, M. & Zhang, M. Tandem PDZ repeats in glutamate receptor-interacting proteins have a novel mode of PDZ domain-mediated target binding. Nature Struct. Biol. 10, 972–978 (2003).

What is postsynaptic density (PSD)?

The postsynaptic density (PSD) of brain excitatory synapses contains many PDZ proteins, of which PSD-95 is the best characterized. PSD-95 contains multiple domains that mediate its association with various membrane proteins (receptors, ion channels and cell-adhesion molecules) and cytoplasmic signalling molecules.