How common is PAI-1 4G 4G?

How common is PAI-1 4G 4G?

TABLE 2. PAI-1 Genotypes and PAI-1 Allele Frequencies in Stroke Cases and Controls

Study A Study B
Stroke Patients Stroke Patients
PAI-1 allele frequency
4G 0.66 0.61
5G 0.34 0.39

What is plasminogen inhibitor PAI-1 4G 5G?

Background and Purpose— Plasminogen activator inhibitor type 1 (PAI-1) is the main inhibitor of fibrinolysis, and high levels may increase the risk of cardiovascular disease. The 4G/5G polymorphism affects PAI-1 gene transcription with lower levels of plasma PAI-1 in the presence of the 5G allele.

What is PAI-1 deficiency?

Complete plasminogen activator inhibitor 1 deficiency (complete PAI-1 deficiency) is a disorder that causes abnormal bleeding. In people with this disorder, bleeding associated with injury can be excessive and last longer than usual.

How do I lower my PAI-1 level?

In vitro studies have shown that statins increase tPA and decrease PAI-1 levels. This effect involves geranylgeranyl transferase inhibition. The mechanism by which statins treatment reduces PAI-1 is different from those that increase t-PA (16).

What is pai1 deficiency?

What is Pai deficiency?

What is the PAI-1 4G polymorphism?

This polymorphism is a single guanine deletion/insertion polymorphism (4G/5G) in the promoter of the plasminogen activator inhibitor type 1 (PAI-1) gene, situated 675 base pairs upstream from the transcriptional start site (PAI-14G/5G). The 4G allele is associated with enhanced gene expression, resulting in increased plasma levels of PAI-1.

What is the prognosis for patients with PAI-1 4G/4G syndrome?

Survival analysis showed that patients with the PAI-1 4G/4G genotype presented lower 30-day survival (Chi-square = 8.82; Hazard ratio = 1.9 (95% CI = 1.17–2.95); p = 0.003) and lower 6-month survival (Chi-square = 8.82; p = 0.003) than those with other genotypes (Chi-square = 11.4; Hazard ratio = 1.9 (95% CI = 1.24–2.88); p<0.001) (Fig 1).

What is the function of PAI-1?

PAI-1 plays an important role in aging and is secreted in senescent cells. Prolonged lifespan has been demonstrated in the PAI-1 deficient murine model. 29 Berne, Indiana, is home to the largest kindred with the loss of function mutation on the PAI-1 gene, SERPIN1 (c.699_700dupTA).

Is the 4G/4G genotype associated with higher plasma PAI-1 concentrations and mortality?

The 4G/4G Genotype of PAI-1 Polymorphism Is Associated with Higher Plasma PAI-1 Concentrations and Mortality in Patients with Severe Sepsis NCBI