How do loop diuretics affect calcium?

How do loop diuretics affect calcium?

Loop diuretics inhibit the Na-K-2Cl transporter and also increase calcium excretion. They are often used in the treatment of hypercalcemia. Thiazide diuretics block the thiazide-sensitive NaCl transporter in the distal convoluted tubule, and can decrease calcium excretion.

How does loop diuretics cause hypocalcemia?

Thiazide diuretics can cause hypercalcemia while loop diuretics increase the excretion of calcium which can lead to hypocalcemia.

Why do loop diuretics decrease calcium reabsorption?

Loop diuretics reduce the lumen-positive transepithelial voltage and consequently diminish paracellular transport of calcium and magnesium (12).

Why do loop diuretics treat hypercalcemia?

Furosemide is a loop diuretic agent that has been used to treat hypercalcemia because it increases renal calcium excretion. The effect of furosemide on calcium transport molecules in distal tubules has yet to be investigated.

Can diuretics increase calcium levels?

Diuretics: Thiazide diuretics like hydrochlorothiazide (Microzide) and chlorthalidone are used to treat high blood pressure, but high calcium levels are a well-known side effect. These medications can raise calcium levels by preventing calcium from being released in the urine, which can also lead to kidney stones.

Why do diuretics cause hypercalcemia?

Thiazide diuretics can increase renal tubular reabsorption of calcium, resulting in hypercalcemia.

How does HCTZ increase calcium?

By increasing calcium reabsorption from the luminal membrane into the interstitium in exchange for sodium, thiazides reduce urine calcium levels and increase blood calcium.

What does HCTZ do to calcium?

Thiazides work by increasing calcium reabsorption at the level of the distal renal tubule and, thus, lowering urinary calcium. Hydrochlorothiazide (HCTZ) is the agent most commonly used, but other thiazide or thiazide-type diuretics can be administered, including trichlormethiazide and chlorthalidone.

What does hydrochlorothiazide do to calcium?

Addition of hydrochlorothiazide (1 mg/kg) reduced their urinary calcium excretion and maintained their serum calcium concentrations near the lower limit of normal, allowing the 1,25-dihydroxyvitamin D(3) and 1alpha-hydroxyvitamin D(3) doses to be reduced, and it alleviated their symptoms.

What diuretics reduce calcium?

What are loop diuretics?

Loop diuretics are diuretics that act at the ascending limb of the loop of Henle in the kidney. They are primarily used in medicine to treat hypertension and edema often due to congestive heart failure or chronic kidney disease.

Do diuretics raise calcium?

What drugs are loop diuretics?


  • Torsemide,
  • Bumetanide,
  • Axosemide,
  • Tripamide,
  • Piretanide,
  • Ethacrynic acid.
  • Why loop diuretics promote calcium excretion?

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    What are loop diuretics used for?

    The medicine Loop diuretic is used to treat Ventricular Septal Defect

    Can Demerol be used with a loop diuretic?

    Loop Diuretics. Disrupt sodium reabsorption in the Loop of Henle in the kidneys. Meperidine (Demerol) Used to relieve moderate to severe pain. It is in a class of