How do you administer PEG asparaginase?

How do you administer PEG asparaginase?

Pegaspargase is given as an injection into a large muscle (intramuscular or IM). Depending on your dose, the medication may need to be divided into two injections. Pegaspargase may be given into the vein as an infusion (intravenous or IV). There is no pill form of pegaspargase.

What is pegylated asparaginase?

Listen to pronunciation. (… as-PAYR-uh-jih-NAYS) A drug used with other drugs to treat adults and children with acute lymphoblastic leukemia.

Why is asparaginase used in the treatment of leukemia?

Asparaginase is used to treat acute lymphocytic leukemia (ALL). It works by starving tumor cells of needed nutrients and slowing tumor cell growth.

Is pegaspargase a chemotherapy drug?

PEGASPARGASE (peg AS par jase) is a chemotherapy drug. This medicine is used to treat acute lymphoblastic leukemia (ALL).

What is 6 mercaptopurine used for?

Mercaptopurine is used alone or with other chemotherapy drugs to treat acute lymphocytic leukemia (ALL; also called acute lymphoblastic leukemia and acute lymphatic leukemia; a type of cancer that begins in the white blood cells). Mercaptopurine is in a class of medications called purine antagonists.

What is a peg infusion?

With this method, a feeding pump is set up and connected to the PEG tube. The formula is infused over a prescribed period of time into the patient. The risk for aspiration is decreased because less formula is given during a more prolonged period of infusion.

What is a pegylated drug?

PEGylation is a pharmaceutical technology that involves the covalent attachment of polyethylene glycol (PEG) to a drug to improve its pharmacokinetic, pharmacodynamic, and immunological profiles, and thus, enhance its therapeutic effect.

What does peg stand for in PEG asparaginase?

Abstract. Polyethylene glycol (PEG)-L-asparaginase, at doses ranging from 500 to 8000 units/m2, was infused iv over 60 min in 31 patients of whom 27 were evaluable pharmacokinetically.

How often is asparaginase given?

You usually have asparaginase every 2 to 3 weeks. You often have it in combination with other chemotherapy drugs such as doxorubicin, methotrexate and cytarabine.

Why is etoposide called VP 16?

Etoposide was first synthesized in 1966 and U.S. Food and Drug Administration approval was granted in 1983. The nickname VP-16 likely comes from a compounding of the last name of one of the chemists who performed early work on the drug (von Wartburg) and podophyllotoxin.

How often is Pegaspargase given?

Pegaspargase comes as a liquid to be injected into a muscle or infused intravenously (into a vein) over 1 to 2 hours by a doctor or nurse in a medical office or hospital outpatient clinic. It is usually given not more often than once every 2 weeks.

What are the side effects of Pegaspargase?

Pegaspargase side effects

  • easy bruising, unusual bleeding, purple or red spots under your skin;
  • low white blood cell counts–fever, mouth sores, skin sores, sore throat, cough, trouble breathing;

What is the recommended dose of pegasparaginase?

Targeting a trough PEGasparaginase activity level of 100 IU/L, the loading dose recommended during induction is 800 IU/m2followed by a biweekly maintenance dose of 600 IU/m2.

What is the normal range of asparaginase activity?

In order to target an asparaginase activity level of 100 IU/L, a loading dose of 800 IU/m2(induction) and 600 IU/m2(intensification) is advised. In conclusion, variability of PEGasparaginase activity levels can be explained by body surface area, the treatment phase and the occurrence of an infection.

What is the preferred route of administration for Peg asparaginase?

Administration: IV or IM injection – IV administration is the recommended route of administration for PEG asparaginase for the Atlantic Provinces pediatric populations unless otherwise specified by the treatment protocol being followed for each patient.

What is the prevalence of asparaginase HSRs?

Asparaginase HSRs are more common in adults than children. Intramuscular (IM) administration decreases the risk of anaphylaxis compared to intravenous (IV) administration. The BC Cancer Agency Cancer Drug Manual (2001) reports asparaginase produces HSRs in 6- 43% of all patients with a reduction to 6-18% in children with IM injection.