Is ferritin a micelle?
Ferritin is a protein containing about 20 % by weight of iron in the form of a micelle of ferric hydroxide: this is surrounded by a shell of apoferritin. The iron can be removed and the apoferritin crystallised as colourless octahedra similar to the brown octahedral crystals formed by ferritin.
What is the function of ferritin?
Ferritin is a protein that stores iron inside your cells. You need iron to make healthy red blood cells. Red blood cells carry oxygen from your lungs to the rest of your body. Iron is also important for healthy muscles, bone marrow, and organ function.
Where is ferritin located?
The greatest concentrations of ferritin are typically in the cells of the liver (known as hepatocytes) and immune system (known as reticuloendothelial cells). Ferritin is stored in the body’s cells until it’s time to make more red blood cells. The body will signal the cells to release ferritin.
Where is ferritin stored in the body?
Ferritin is found in the liver, spleen, skeletal muscles, and bone marrow. Only a small amount of ferritin is found in the blood. The amount of ferritin in the blood shows how much iron is stored in your body.
Where is ferritin found and what is its function?
Ferritin is found in most tissues as a cytosolic protein, but small amounts are secreted into the serum where it functions as an iron carrier. Plasma ferritin is also an indirect marker of the total amount of iron stored in the body; hence, serum ferritin is used as a diagnostic test for iron-deficiency anemia.
What is the impact of ferritin?
High levels of ferritin can damage your joints, heart, liver, and pancreas. Too much iron is most often caused by an inherited disease called hemochromatosis. Many people with this disease never have any symptoms, especially women who lose iron through menstruation.
Where does ferritin come from?
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood (2010) 116 (9): 1574–1584. The serum ferritin concentration is a clinical parameter measured widely for the differential diagnosis of anemia.
How does the body make ferritin?
One major trigger for the production of many ferritins is the mere presence of iron; an exception is the yolk ferritin of Lymnaea sp., which lacks an iron-responsive unit. Free iron is toxic to cells as it acts as a catalyst in the formation of free radicals from reactive oxygen species via the Fenton reaction.
How is iron transported in the body?
Transferrin is the major iron transport protein (transports iron through blood). Once inside cells, the iron can be used for cellular purposes (cofactor for enzyme etc.) or it can be stored in the iron storage proteins ferritin or hemosiderin.
Where is ferritin found?
Where is ferritin found in the body?
liver
Ferritin is a protein in the body that binds to iron; most of the iron stored in the body is bound to ferritin. Ferritin is found in the liver, spleen, skeletal muscles, and bone marrow. Only a small amount of ferritin is found in the blood.
How does ferritin store iron?
Within cells, iron is stored in a protein complex as ferritin or the related complex hemosiderin. Apoferritin binds to free ferrous iron and stores it in the ferric state. As ferritin accumulates within cells of the reticuloendothelial system, protein aggregates are formed as hemosiderin.
How does gastric acid affect pea ferritin iron bioavailability?
CONCLUSION: Under gastric conditions, the iron core of pea ferritin is released into the digestive medium due to acid induced structural alterations and dissociation of protein. The released iron interacts with dietary factors leading to modulation of pea ferritin iron bioavailability, resembling the typical characteristics of non-heme iron.
Why do plants increase ferritin levels in plants?
Therefore, increasing the expression level of ferritin in plants is thought to increase the iron density of the staple grains and thereby the iron intake of iron deprived populations as well[8].
Does Caco-2 cell ferritin formation predict nonradiolabeled food iron availability?
Caco-2 cell ferritin formation predicts nonradiolabeled food iron availability in an in vitro digestion/Caco-2 cell culture model. J Nutr. 1998;128:1555–1561. [PubMed] [Google Scholar] 24. Chitchumroonchokchai C, Schwartz SJ, Failla ML.
Is iron in ferritin or salts equally bioavailable in nonanemic women?
Davila-Hicks P, Theil EC, Lönnerdal B. Iron in ferritin or in salts (ferrous sulfate) is equally bioavailable in nonanemic women. Am J Clin Nutr. 2004;80:936–940. [PubMed] [Google Scholar] 31. Fleming MD, Trenor CC, Su MA, Foernzler D, Beier DR, Dietrich WF, Andrews NC.