Is pfam a secondary database?

Is pfam a secondary database?

Pfam is a database of curated protein families, each of which is defined by two alignments and a profile hidden Markov model (HMM). In an effort to be comprehensive, automatically generated entries, called Pfam-B, are built from sequence clusters not currently covered by Pfam-A entries.

What is a domain in a protein?

Domains are distinct functional and/or structural units in a protein. Usually they are responsible for a particular function or interaction, contributing to the overall role of a protein. Domains may exist in a variety of biological contexts, where similar domains can be found in proteins with different functions.

What is the source of protein structure in SCOP and CATH?

Inner nodes represent sets of protein domains which are clustered together on a specific level of the hierarchy. For SCOP, inner nodes represent classes, folds, superfamiles or families. For CATH, inner nodes correspond to classes, architectures, topologies and homologous superfamilies.

What is my methodology?

The methodology describes the broad philosophical underpinning to your chosen research methods, including whether you are using qualitative or quantitative methods, or a mixture of both, and why.

What is difference between Motif and domain?

A motif is similar 3-D structure conserved among different proteins that serves a similar function. Domains, on the other hand, are regions of a protein that has a specific function and can (usually) function independently of the rest of the protein.

Is Prosite a secondary database?

PROSITE and PRINTS are the only manually annotated secondary databases. The print is a diagnostic collection of protein fingerprints.

What are the types of secondary data?

There are two common types of secondary data: Internal data and External data. Internal data is the information that has been stored or organized by the organization itself. External data is the data organized or collected by someone else.

What is a secondary database?

Secondary databases make use of publicly available sequence data in primary databases to to provide layers of information to DNA or protein sequence data. Secondary databases comprise data derived from analysing entries in primary databases.

How do you write a methodology essay?

  1. Step 1: Explain your methodological approach. Begin by introducing your overall approach to the research.
  2. Step 2: Describe your methods of data collection and/or selection.
  3. Step 3: Describe your methods of analysis.
  4. Step 4: Evaluate and justify your methodological choices.

Which tool is required to search protein motifs in a set of protein sequences?

PhosphoSite — A bioinformatics resource dedicated to physiological protein phosphorylation. Find information about polyglutamine (polyQ) repeats. Find the presence of protein motifs and patterns in an amino acid sequence.

What is secondary data example?

Secondary data refers to data that is collected by someone other than the primary user. Common sources of secondary data for social science include censuses, information collected by government departments, organizational records and data that was originally collected for other research purposes.

Is InterPro a secondary database?

The InterPro ( (3) database was created to unite secondary databases that contain overlapping information on protein families, domains and functional sites (Table 1). InterPro entries are divided into groups based on the protein families or the domains that the signatures represent.

What is a methodology in an essay?

Essay methodology is defined as the process that an author uses to produce an essay or research paper. This methodology may differ significantly and is dependent on the topic and the purpose of the work. The first step of essay methodology is to refine one’s topic.

Is secondary data qualitative or quantitative?

Primary data and secondary data can be either quantitative. (numerical) or qualitative. (verbal).

What is a motif in proteins?

A protein sequence motif is an amino-acid sequence pattern found in similar proteins; change of a motif changes the corresponding biological function.

What is Domain give example?

A domain name takes the form of two main elements. For example, the domain name consists of the website’s name (Facebook) and the domain name extension (.com). When a company (or a person) purchases a domain name, they’re able to specify which server the domain name points to.

How do you structure a methodology?

Therefore, no matter what subject area you’re working in, your methodology section will include the following:

  1. A recap of your research question(s)
  2. A description of your design or method.
  3. The background and rationale for your design choice.
  4. An evaluation of your choice of method, and a statement of its limitations.

What is domain in gene?

Listen to pronunciation. (doh-MAYN) A specific physical region or amino acid sequence in a protein which is associated with a particular function or corresponding segment of DNA.