Is the flu virus mRNA?
The influenza A virus RNA-dependent RNA polymerase produces capped and polyadenylated mRNAs in the nucleus of infected cells that resemble mature cellular mRNAs, but are made by very different mechanisms.
What is the role of Trex in relation to mRNA?
The TREX (TRanscription-EXport) complex is an evolutionarily conserved multiprotein complex that plays a major role in the functional coupling of different steps during mRNA biogenesis, including mRNA transcription, processing, decay, and nuclear export.
Does Trex make pre mRNA?
The TREX complex, which functions in mRNA export, is recruited to mRNA during splicing. Together, our data raise the possibility that pre-mRNA undergoes splicing in nuclear speckle domains, before their release by TREX components for efficient export to the cytoplasm.
What is Trex biochemistry?
Abstract. TRanscription and EXport (TREX) is a conserved multisubunit complex essential for embryogenesis, organogenesis and cellular differentiation throughout life. By linking transcription, mRNA processing and export together, it exerts a physiologically vital role in the gene expression pathway.
Is the Covid vaccine the first mRNA vaccine?
Thanks to decades of research and innovation, mRNA vaccine technology was ready. With COVID, this technology got its moment and has proven to be extremely safe and effective. Pfizer’s COVID-19 vaccine is the first mRNA product to achieve full FDA approval in the U.S.
What vaccines are mRNA Besides Covid?
- Companies are studying the technology behind the Pfizer and Moderna COVID-19 vaccines for other uses. This includes HIV, the flu, and even cancer.
- Many of these vaccines are just getting started in human clinical trials.
- Moderna’s cytomegalovirus (CMV) vaccine appears to be furthest along.
Where are introns found?
Introns are found in the genes of most organisms and many viruses and can be located in a wide range of genes, including those that generate proteins, ribosomal RNA (rRNA) and transfer RNA (tRNA).
What are introns good for?
Introns regulate all levels of their host gene expression, including transcription, export, RNA stability, and even translation through the exon junction complex. Introns can also act beyond their host genes.
What’s the purpose of introns?
Introns, from this perspective, have a profound purpose. They serve as hot spots for recombination in the formation of new combinations of exons. In other words, they are in our genes because they have been used during evolution as a faster pathway to assemble new genes.
Can I get another vaccine after Covid vaccine?
Can I get other vaccines, like the flu shot, at the same time as the COVID-19 vaccine? No, you will need to wait two weeks after getting the COVID-19 vaccine before getting other immunizations.
What is the NXF1 gene?
Nuclear RNA export factor 1, also known as NXF1 or TAP, is a protein which in humans is encoded by the NXF1 gene. This gene is one member of a family of nuclear RNA export factor genes.
How is NXF1 recruited to mRNA in human cells?
TREX is the major complex used to recruit Nxf1 to mRNA in human cells. the organization of the NXF1 proline-tyrosine nuclear localization signal reveal unexpected redundancy in the nuclear import pathways used by NXF1. The U2AF65 protein served as an adaptor to link expanded CAG RNA to NXF1 for RNA export.
What is tap (NXF1)?
^ Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (December 2000). “TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture”. Molecular and Cellular Biology. 20 (23): 8996–9008. doi: 10.1128/MCB.20.23.8996-9008.2000. PMC 86553. PMID 11073998.
What is the role of NXF1 in the IRF5 signaling pathway?
Gain or loss-of-function experiments revealed NXF1 selectively regulates TLR7-driven IRF5 transcriptional activity, suggesting a new role for NXF1 in the IRF5 signaling pathway. repeat RNA-sequestration of SRSF1 triggers the NXF1-dependent nuclear export of C9ORF72 transcripts retaining expanded hexanucleotide repeats