What are formin proteins?

What are formin proteins?

Formin proteins: a domain-based approach Formin proteins are potent regulators of actin dynamics. Most eukaryotes have multiple formin isoforms, suggesting diverse cellular roles. Formins are modular proteins, containing a series of domains and functional motifs. The Formin homology 2 (FH2) domain binds actin filament barbed ends and moves …

What is the function of the formin 1 gene?

This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration.

What is the function of the formin homology 2 domain?

Formins are modular proteins, containing a series of domains and functional motifs. The Formin homology 2 (FH2) domain binds actin filament barbed ends and moves … Formin proteins are potent regulators of actin dynamics. Most eukaryotes have multiple formin isoforms, suggesting diverse cellular roles.

What is the connection between profilin and formins?

The initial hint of a connection between profilin and formins came from a study employing a profilin-coupled affinity matrix and it was subsequently shown to have a role together with the fly formin Cappuccino during oogenesis in Drosophila [10], [11].