What does HER2 CEP17 ratio mean?

What does HER2 CEP17 ratio mean?

When the ratio of HER2/CEP17 was ≥2.0 or the average HER2 gene copy number/tumor cell was ≥6.0 with a ratio of HER2/CEP17 <2.0, the HER2 status was classified as positive. When the ratio of HER2/CEP17 was <2.0 with an average HER2 signals/cell <4.0, the HER2 status was considered negative.

Is it better to be HER2-positive or negative?

Is HER2-positive breast cancer good or bad? HER2-positive cancer tends to be poorer in terms of prognosis than HER2-negative cancer because: It grows faster. It is more likely to spread to the lymph nodes fast.

What does HER2 neu stand for?

HER2 stands for human epidermal growth factor receptor 2. It is a gene that makes a protein found on the surface of all breast cells. It is involved in normal cell growth.

What does HER2/neu negative mean?

When a breast cancer is HER2-negative, it means that the cancerous cells do not contain high levels of the protein HER2. There are many treatment options available for this type of breast cancer, but the outlook can vary.

When is HER2 repeated?

According to the 2018 updated guidelines, repeat HER2 testing may be performed on the excisional biopsy if the tumor is grade 3, the amount of invasive tumor in the core biopsy is small, the resection contains morphologically distinct high-grade carcinoma, or there are quality concerns related to the HER2 testing …

Who makes trastuzumab?

Genentech: Herceptin® (trastuzumab) – Information for Patients.

How is HER2 status determined?

Although complicated, HER2 status is basically determined by IHC results in the dual-probe ISH groups 2 to 4. While cases with HER2 IHC 3+ are regarded as HER2 positive, those with HER2 IHC 0 or 1+ are regarded as HER2 negative. In cases with HER2 IHC 2+, an additional observer blinded to previous result recounts ISH.

What is FISH analysis breast cancer?

The FISH (fluorescence in situ hybridization) test checks the DNA of your cancer cells for extra copies of the HER2/neu gene. This gene makes proteins called HER2 (human epidermal growth factor receptor 2) that attach to the surface of all breast cells.

How do you read HER2 FISH results?


  1. Positive HER2 amplification: FISH ratio is greater than 2.2 or HER2 gene copy is greater than 6.0.
  2. Equivocal HER2 amplification: FISH ratio of 1.8-2.2 or HER2 gene copy of 4.0-6.0.
  3. Negative HER2 amplification: FISH ratio is less than 1.8 or HER2 gene copy of less than 4.0.

What does HER2 FISH positive mean?

FISH testing usually returns one of two results: positive or negative. Positive means your breast cancer cells make too much HER2 and your doctor should treat you with drugs that target that protein. Negative means the protein isn’t involved in the growth of your tumor.

Can HER2-positive be cured?

HER2-positive breast cancer is highly curable because of the availability of these HER2-targeted therapies, so we treat patients fairly aggressively upfront to reduce the risk of them experiencing a stage IV recurrence.

How long is chemo for HER2-positive?

Cycles can last anywhere from about two to four weeks, depending on the combination of drugs. Chemotherapy generally lasts about three to six months. The total length of chemotherapy treatment may vary depending on the stage of breast cancer and a number of other factors.

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