What is losartan Hydrochlorothiazide used for?
Losartan and hydrochlorothiazide combination is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly.
What is losartan mechanism of action?
Mechanism Of Action Losartan and its principal active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor found in many tissues, (e.g., vascular smooth muscle, adrenal gland).
What is the difference between losartan and losartan HCTZ?
Losartan relaxes the blood vessels and lowers the blood pressure. A lower blood pressure will increase the supply of blood and oxygen to the heart. Hydrochlorothiazide is a thiazide diuretic (water pill) . It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.
Is it OK to take losartan and hydrochlorothiazide together?
In conclusion, the losartan/HCTZ combination was safe and effective in controlling morning hypertension in Very-Elderly as well as Young/Elderly patients. In addition, combination therapy was also superior to high-dose therapy for lowering morning SBP in Very-Elderly patients.
Where is losartan absorbed?
Losartan is readily absorbed from the gastrointestinal tract after oral doses, but undergoes substantial first-pass metabolism resulting in a systemic bioavailability of about 33%.
What is losartan potassium HCTZ?
Losartan is an angiotensin receptor blocker (ARB) and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a “water pill” (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.
Is there a recall on losartan HCTZ 100 25 mg?
In December, the FDA announced a voluntary recall of losartan potassium tablets USP. In November, the FDA announced a voluntary recall of losartan potassium/hydrochlorothiazide, 100 mg/25 mg tablets in 1,000-count plastic bottles, NDC 0781-5207-10, Lot number JB8912, Exp. Date 06/2020.
What is the brand name for losartan hydrochlorothiazide?
Hyzaar (losartan / hydrochlorothiazide) is a combination medication that contains two drugs, losartan and hydrochlorothiazide. Losartan is an angiotensin II receptor blocker (ARB). It blocks a chemical that causes blood vessels to tighten. When this chemical is blocked, blood vessels relax, lowering blood pressure.
Does losartan cause weight gain?
Yes. Losartan causes weight fat loss by reducing blood cholesterol levels. More specifically, it lowers the amount of bad cholesterol and triglyceride circulating in the blood and fat deposits in the adipose tissue. ARBs also restrict the amount of angiotensin-converting enzymes (ACE) in the body.
Is it better to take losartan at night or morning?
Your doctor may suggest that you take your first dose before bedtime, because it can make you dizzy. After the very first dose, you can take losartan at any time of day. Try to take it at the same time every day. You can take losartan tablets with or without food.
What are the dangers of taking losartan?
Side Effects
- Blurred vision.
- difficult breathing.
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position.
- fast or irregular heartbeat.
- nausea or vomiting.
- numbness or tingling in the hands, feet, or lips.
- stomach pain.
- weakness or heaviness of the legs.
How do you know if losartan is working?
Losartan starts to reduce high blood pressure after about 6 hours but it may take 3 to 6 weeks to fully take effect. If you have high blood pressure, you may not have any symptoms. In this case, you may not feel any different when you take losartan.