What is quinoline structure?
C9H7NQuinoline / Formula
What are quinoline derivatives?
Quinoline derivatives are considered broad-spectrum pharmacological compounds that exhibit a wide range of biological activities. Integration of quinoline moiety can improve its physical and chemical properties and also pharmacological behavior.
What is the functional group of quinoline?
quinoline, any of a class of organic compounds of the aromatic heterocyclic series characterized by a double-ring structure composed of a benzene and a pyridine ring fused at two adjacent carbon atoms. The benzene ring contains six carbon atoms, while the pyridine ring contains five carbon atoms and a nitrogen atom.
How is quinoline formed?
Quinolines may be obtained by the Skraup synthesis. This involves heating aniline or a substituted aniline with glycerol in the presence of sulphuric acid, ferrous sulphate and nitrobenzene. The reaction is complex. It involves dehydration of glycerol by means of sulphuric acid to give acrolein.
What is quinoline found in?
The quinoline alkaloids are mainly found in plants, as in Rutaceae and Rubiaceae, but also in microorganisms and animals. Quinoline is furthermore comprised as a partial structure in the redox factor PQQ (pyrroloquinoline quinone) and in quinoenzymes.
How many nitrogen and oxygen atoms are in quiNINE?
In the case of quiNINE chemical formula C 20 H. 24 N 202 See stamps for carbon. So we have 20 carbon atoms. We have 24 hydrogen atoms, two nitrogen atoms and two oxygen atoms.
Why is quinoline important?
Quinoline has been found to possess antimalarial, anti-bacterial, antifungal, anthelmintic, cardiotonic, anticonvulsant, anti-inflammatory, and analgesic activity.
Is quinoline same as chloroquine?
Chloroquine (CQ) is a quinoline-based drug widely used for the prevention and treatment of malaria.
How is chloroquine synthesized?
Chloroquine, 7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline (37.1. 3), is made by reacting 4,7-dichloroquinoline (37.1. 1.1) with 4-diethylamino-1-methylbutylamine (37.1. 1.2) at 180 °C [1–3].
What is the pH of quinine?
A 27; solution of quinine hydrochloride was found to have a pH of 6.1. dihydrochloride 2.6 and bisulphate 2.4. It will be also noted that the pH figures all lie within the pH ranges of the human stomach and duodenum, as reported by McClendon,” Hunie, Denis, Silver- nian and Irwin,’ and others.
How does quinine work in the body?
Quinine is used to treat malaria caused by Plasmodium falciparum. Plasmodium falciparum is a parasite that gets into the red blood cells in the body and causes malaria. Quinine works by killing the parasite or preventing it from growing.
Do quinoline derivatives have biological activity?
Biological activities of quinoline derivatives Quinoline and its fused heterocyclic derivatives tested with diverse pharmacological activity functional groups constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activi …
What is quinoline made of?
… (Show more) quinoline, any of a class of organic compounds of the aromatic heterocyclic series characterized by a double-ring structure composed of a benzene and a pyridine ring fused at two adjacent carbon atoms. The benzene ring contains six carbon atoms, while the pyridine ring contains five carbon atoms and a nitrogen atom.
What is the difference between quinoline and pyridine?
Quinoline. The benzene ring contains six carbon atoms, while the pyridine ring contains five carbon atoms and a nitrogen atom. The simplest member of the quinoline family is quinoline itself, a compound with molecular structure C 9 H 7 N. Quinoline is used principally for the manufacture of nicotinic acid, which prevents pellagra in humans,…
How many single bonds are there in quinoline?
Quinoline consists of a benzene ring fused to the alpha-beta-position of the pyridine ring. In the quinoline structure, there are five double bonds present and eleven single bonds are present. The single bonds are sigma bonds formed by the head-on overlapping.