What is the best statin to take with the least side effects?
In the analysis of 135 previous studies, which included nearly 250,000 people combined, researchers found that the drugs simvastatin (Zocor) and pravastatin (Pravachol) had the fewest side effects in this class of medications. They also found that lower doses produced fewer side effects in general.
What are the best tolerated statins?
Among individual statins, simvastatin and pravastatin seem safer and more tolerable than other statins.
What is the safest cholesterol-lowering medication?
Still, all in all, the statins are the safest and best tolerated of all cholesterol-lowering medications.
Is there a better statin than atorvastatin?
Atorvastatin and simvastatin are both effective statin drugs for lowering blood cholesterol. However, atorvastatin is considered a more potent statin. Atorvastatin lasts longer in the body and can be taken in the morning or at night.
Which statin has least muscle side effects?
Simvastatin is the most likely to cause muscle pain, and fluvastatin and pitavastatin are the least likely.
Which is safer atorvastatin or rosuvastatin?
Atorvastatin was the safest statin as it resulted in the least number of patients at the end of 2 years of treatment with the new onset of microalbuminuria (10.9%) followed by rosuvastatin (14.3%) and then pravastatin (26.6%).
Which statin has the lowest risk of myalgia?
While pravastatin and fluvastatin may be associated with the lowest incidence of myalgia, the LDL-lowering effect is low compared to other statins.
Is rosuvastatin more effective than atorvastatin?
Efficacy. At the end of the titration-to-goal period, rosuvastatin was significantly more effective than atorvastatin on the primary efficacy measure, reducing LDL-C by 52% compared with 46% in the atorvastatin group (p < 0.0001) (table
Is 20 mg of atorvastatin a lot?
Adults—At first, 10 or 20 milligrams (mg) once a day. Some patients may need to start at 40 mg per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 80 mg per day.
Does rosuvastatin have less side effects than atorvastatin?
There was no significant difference between rosuvastatin and a 4 times higher dose of atorvastatin (1:4 dose ratio). There were no significant differences between rosuvastatin and atorvastatin at any dose ratio for adverse events.
Why was Crestor taken off the market?
Initial reports indicate the patient died of a muscle-damaging disease linked to Crestor and all other members of the family of cholesterol-lowering drugs known as statins. The same side disease, rhabdomyolysis, drove the cholesterol-lowering drug Baycol off the market.
Is there a non statin cholesterol medication?
There are many non-statin medications your doctor might prescribe: Bile acid-binding resins, like cholestyramine (Locholest, Prevalite, Questran), colesevelam (WelChol), and colestipol (Colestid) stick to cholesterol-rich bile acids in your intestines and lower your LDL levels.
Which statin has the least amount of side effects?
According to a research review people who take simvastatin (Zocor) or pravastatin (Pravachol) may experience fewer side effects. Guidelines issued by the American College of Cardiology and American Heart Association indicate that the benefits of a high-intensity statin outweigh the risks if:
Do statins have a’nocebo’effect?
However, researchers have found a “nocebo” effect when it comes to perceived muscle pain and statins. A “nocebo” effect means people who have negative expectations about a medication report experiencing the potential side effect at higher rates than the drug should cause.
What are the side effects of statins on muscles?
Potency Of Statins Linked To Muscle Side Effects. These include commonly reported problems such as pain and weakness, as well as life-threatening muscle breakdown, known as rhabdomyolysis. Statin myopathies can significantly increase pain and injury risk and affect mobility, especially in older individuals.
What happens if you change the dose of a statin?
Change your dose. Lowering your dose may reduce some of your side effects, but it may also reduce some of the cholesterol-lowering benefits your medication has. Another option is to take the medication every other day, especially if you take a statin that stays in the blood for several days.