What is the function of SMAD4?
In the nucleus, the SMAD protein complex binds to specific areas of DNA where it controls the activity of particular genes and regulates cell growth and division (proliferation). By controlling these cellular processes, the SMAD4 protein is involved in the development of many body systems.
What is SMAD3 gene?
The SMAD3 gene provides instructions for making a protein involved in transmitting chemical signals from the cell surface to the nucleus.
What does MLH1 stand for?
The name MLH1 stands for “MutL homolog 1.” The gene is located on chromosome 3. The MLH1 gene protein plays an important role in repairing DNA damage.
What does SMAD4 stand for?
Mothers against decapentaplegic homolog 4
|Aliases||SMAD4, DPC4, JIP, MADH4, MYHRS, SMAD family member 4|
|External IDs||OMIM: 600993 MGI: 894293 HomoloGene: 31310 GeneCards: SMAD4|
|showGene location (Human)|
|showGene location (Mouse)|
Is SMAD4 a structural protein?
A Smad4-specific sequence insertion within the MH2 domain interacts with the C-terminal tail to form a structural extension from the core. A tandem sulfate-ion-binding site was identified within the subunit interface, which may interact with the phosphorylated C-terminal sequence of pathway-restricted SMAD proteins.
Is SMAD4 a tumor suppressor gene?
SMAD4 (DPC4) is a tumor suppressor gene. It is located at chromosome 18q21. 1 and a member of the SMAD family. Which mediates the TGF-β signaling pathway, thereby controlling the growth of epithelial cells.
What is Decapentaplegic DPP expression?
Decapentaplegic (Dpp) is a key morphogen involved in the development of the fruit fly Drosophila melanogaster and is the first validated secreted morphogen. It has also been suggested that Dpp plays a role in regulating the growth and size of tissues.
Is TGF beta a cytokine?
Transforming growth factor β (TGF-β) is a highly pleiotropic cytokine that plays an important role in wound healing, angiogenesis, immunoregulation and cancer. The cells of the immune system produce the TGF-β1 isoform, which exerts powerful anti-inflammatory functions, and is a master regulator of the immune response.
Can Lynch syndrome skip a generation?
Because Lynch syndrome is hereditary, there is a 50% chance that a person will pass on the mutation to each of his or her children. Lynch syndrome does not skip generations. Males and females are equally likely to be affected.
Is MLH1 a tumor suppressor?
MLH1 is a tumor suppressor gene involved in DNA mismatch repair. Germline mutations in this gene are known to cause Lynch syndrome. The most common malignancies in Lynch syndrome are colorectal and endometrial carcinomas.
Where is the APC gene located?
The human APC gene is located on the long (q) arm of chromosome 5 in band q22. 2 (5q22. 2). The APC gene has been shown to contain an internal ribosome entry site.
Is SMAD4 an oncogene or tumor suppressor?
SMAD4, recognized as an important tumor suppressor, is a central mediator of transforming growth factor beta (TGFB) and bone morphogenetic protein (BMP) signaling.
Is General Electric’s divestiture the right move for the company?
Sometimes the bold move is the right move, and it’s not always easy to make. In November, General Electric announced plans to divest several business units into their own companies, leaving General Electric focused on aviation.
What’s happening with General Electric’s financials?
Today, the company’s in the midst of a massive transformation, selling chunks of itself to slim down its business and get growth back on track. General Electric recently reported 2021 Q4 earnings, showing that its financials seem to be improving. Here’s what investors need to know as the company prepares for more significant changes.
Does General Electric have enough assets to stand alone?
General Electric still holds additional assets that it could tap into if needed, including stakes totaling roughly $13 billion in value in Baker Hughes and AerCap. Management has noted that it intends to have all three eventual standalone companies carry investment-grade balance sheets.