What is the mechanism of action for clopidogrel?
Mechanism Of Action Clopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets.
What kind of medicine is clopidogrel?
Clopidogrel is a platelet inhibitor. It reduces the chance that a harmful blood clot will form by preventing platelets from clumping together in the blood. Clopidogrel may also increase the chance of serious bleeding in some people.
What is the indication of clopidogrel?
FDA-approved indications for clopidogrel include: Use during a percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) and stable ischemic heart disease. [4][5][6] Primary prevention of thromboembolism atrial fibrillation.
What is the active form of clopidogrel?
The active metabolite of clopidogrel contains a thiol group which binds to a free cysteine on the P2RY12 receptor and irreversibly blocks ADP binding and receptor activation (Fig. 1) [1]. Once this blockage has occurred, platelets are affected for their entire lifespan of approximately 7–10 days.
What is the mechanism of action of atorvastatin?
Mechanism of Action Atorvastatin competitively inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. [2] By preventing the conversion of HMG-CoA to mevalonate, statin medications decrease cholesterol production in the liver.
What does clopidogrel inhibit?
The active metabolite of clopidogrel selectively inhibits the binding of adenosine diphosphate (ADP) to its platelet P2Y12 receptor and the subsequent ADP- mediated activation of the glycoprotein GPIIb/IIIa complex, thereby inhibiting platelet aggregation. This action is irreversible.
Is clopidogrel an anticoagulant or antiplatelet?
About clopidogrel Clopidogrel is an antiplatelet medicine. It prevents platelets (a type of blood cell) from sticking together and forming a dangerous blood clot.
What is the difference between aspirin and clopidogrel?
Aspirin and Plavix (clopidogrel bisulfate) are drugs used to prevent blood clots. Aspirin and Plavix belong to different drug classes. Plavix is an anticoagulant and aspirin is a nonsteroidal anti-inflammatory drug (NSAID). Aspirin also is used to reduce fever, and to treat pain and inflammation in the body.
What is antiplatelet action?
Antiplatelets are a group of medicines that stop blood cells (called platelets) from sticking together and forming a blood clot. Whenever there is an injury in your body, platelets are sent to the site of the injury, where they clump together to form a blood clot. This stops the bleeding in your body.
What is the Iupac name of clopidogrel?
Clopidogrel☆
| Name of the Clinical Form | Clopidogrel hydrochloride |
|---|---|
| IUPAC Name | Methyl (2S)-2-(2-chlorophenyl)-2-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl)acetate |
| CAS Number | 113665-84-2 |
What is the pharmacokinetics of atorvastatin?
Atorvastatin presents a dose-dependent and non-linear pharmacokinetic profile. It is very rapidly absorbed after oral administration. After the administration of a dose of 40 mg, its peak plasma concentration of 28 ng/ml is reached 1-2 hours after initial administration with an AUC of about 200 ng∙h/ml.
What is atorvastatin 10mg for?
Atorvastatin is used along with a proper diet to help lower “bad” cholesterol and fats (such as LDL, triglycerides) and raise “good” cholesterol (HDL) in the blood. It belongs to a group of drugs known as “statins.” It works by reducing the amount of cholesterol made by the liver.
How do I stop taking clopidogrel?
medicines to prevent blood clots,such as aspirin,warfarin,rivaroxaban,apixaban,edoxaban,dabigatran,dipyridamole,ticagrelor or prasugrel
What is the mechanism of action of clarithromycin?
What is the mechanism of action of clarithromycin? This is a macrolide antibiotic and it has an active metabolite. The active hydroxy metabolite works synergistically with the parent compound. It binds reversibly to the 50S Ribosomal subunit and blocks polypeptide synthesis.
What are the side effects of clopidogrel 75 mg?
Collection of blood under the skin
Does clopidogrel interact with other medications?
Severe interactions of clopidogrel include: ombitasvir/paritaprevir/ritonavir, and dasabuvir; Clopidogrel has serious interactions with at least 42 different drugs. Clopidogrel has moderate interactions with at least 141 different drugs. Mild Interactions of clopidogrel include: aspirin rectal; devil’s claw; ethotoin; fluvastatin; fosphenytoin; ginger; ginkgo biloba