Why is liver cancer more common in Asia?

Why is liver cancer more common in Asia?

RESULTS: More than 70% of all new cases of liver cancer were diagnosed in Asia, a region that 75% of all those chronically infected with hepatitis B virus (HBV) in the world. Chronic HBV infection is the main cause of HCC in Asia, where the virus is endemic and vertical transmission is common.

What is the global incidence of hepatocellular carcinoma HCC worldwide?

Rates of HCC increased from 2.7 per 100,000 in 1997 to 8.8 per 100,000 in 2016 in men, and from 0.8 per 100,000 to 2.2 per 100,000 in women. Steady declines in HCC mortality are predicted for East Asia.

Where is HCC most common?

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer. Hepatocellular carcinoma occurs most often in people with chronic liver diseases, such as cirrhosis caused by hepatitis B or hepatitis C infection.

What is HCC in Australia?

Introduction: Hepatocellular carcinoma (HCC) is a leading cause of cancer deaths both globally and in Australia. Surveillance for HCC in atā€risk populations allows diagnosis at an early stage, when potentially curable. However, most Australians diagnosed with HCC die of the cancer or of liver disease.

Is liver cancer more common in Asians?

Asian American men have higher incidence rates of liver cancer as compared to Hispanic, non-Hispanic white, or Asian/Pacific Islander men. Asian male subgroups have higher mortality rates for liver cancer, specifically 54.3 for Vietnamese, 33.9 for Koreans, 23.3 for Chinese, 16.8 for Filipino and 9.3 for Japanese.

Why do Asians have hep C?

Many Asians are at risk for acquiring HCV infection through unsanitary medical practices during childhood or contaminated blood transfusions.

What is the most common cause of hepatocellular carcinoma?

In the US, infection with hepatitis C is the more common cause of HCC, while in Asia and developing countries, hepatitis B is more common. People infected with both viruses have a high risk of developing chronic hepatitis, cirrhosis, and liver cancer.

What percentage of cirrhotic patients develop HCC?

Seventy-four patients developed cirrhosis and 42 patients developed HCC after 10 years. The overall 10-year incidence of cirrhosis and HCC was 16.2% (1.6%/year) and 7.8% (0.8%/year), respectively. The overall incidence of HCC in cirrhotics was 29.7% (3.0%/year), highest within a year of diagnosis of cirrhosis (7.9%).

Is HCC asymptomatic?

HCC is asymptomatic in its early stage, which significantly delays its timely diagnosis. Those diagnosed at the advanced stage of disease are ineligible for curative surgery, and therapeutic options for advanced HCC patients are limited in availability and efficacy5.

What is meant by hepatocellular?

pertaining to or affecting liver cells.

What is the life expectancy of a person with hepatocellular carcinoma?

Unfortunately, HCC is typically diagnosed late in its course, with a median survival following diagnosis of approximately 6 to 20 months. In the United States, 2 years survival is less than 50% and 5-year survival is only 10%.